Paw B H, Zon L I
Division of Hematology-Oncology, Children's Hospital, Boston, Massachusetts, USA.
Curr Opin Hematol. 2000 Mar;7(2):79-84. doi: 10.1097/00062752-200003000-00002.
The zebrafish (Danio rerio) has emerged in recent years as an exciting animal model system for studying vertebrate organ development and, in particular, the development of the hematopoietic system. The combined advantages of developmental biology and genetic screens for mutations in zebrafish have provided insights into early events in hematopoiesis and identified several genes required for normal blood development in vertebrates. As a result of the large-scale mutagenesis screens for developmental mutants, several zebrafish mutants with defects in blood development have been recovered. This review discusses how these blood mutations in zebrafish have given new perspectives on hematopoietic development.
近年来，斑马鱼（Danio rerio）已成为一种令人兴奋的动物模型系统，用于研究脊椎动物器官发育，尤其是造血系统的发育。斑马鱼发育生物学和基因突变筛选的综合优势，为造血早期事件提供了见解，并鉴定出脊椎动物正常血液发育所需的几个基因。通过对发育突变体进行大规模诱变筛选，已获得了几种血液发育存在缺陷的斑马鱼突变体。本文综述讨论了斑马鱼中的这些血液突变如何为造血发育提供了新的视角。
