Charagundla S R, Duvvuri U, Noyszewski E A, Dandora R, Stolpen A H, Leigh J S, Reddy R
Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
J Magn Reson. 2000 Mar;143(1):39-44. doi: 10.1006/jmre.1999.1948.
(17)O-decoupled (1)H spin-echo imaging has been reported as a means of indirect (17)O detection, with potential application to measurement of blood flow and metabolism. In its current form, (17)O decoupling requires large RF amplitudes and a 180 degrees refocusing pulse, complicating its application in volume and surface coils, respectively. To overcome this problem, we have developed an (17)O-decoupled proton stimulated echo sequence ("STEAM decoupling") to allow (17)O detection with a surface coil. A high B(1) amplitude is easily generated, allowing complete decoupling of (17)O and (1)H. Slice-selective, (17)O-decoupled (1)H imaging is readily performed and the sequence is easily adapted for localized spectroscopy. Intrinsic correction for variations in B(1) and further compensation for B(1) inhomogeneity are discussed.
据报道，（17）O去耦（1）H自旋回波成像作为一种间接检测（17）O的方法，在血流量和代谢测量方面具有潜在应用。就其目前的形式而言，（17）O去耦分别需要大的射频幅度和180度重聚焦脉冲，这使其在体线圈和表面线圈中的应用变得复杂。为了克服这个问题，我们开发了一种（17）O去耦质子激发回波序列（“STEAM去耦”），以允许使用表面线圈检测（17）O。很容易产生高B（1）幅度，从而实现（17）O和（1）H的完全去耦。可以轻松执行切片选择的、（17）O去耦（1）H成像，并且该序列很容易适用于局部光谱学。文中讨论了对B（1）变化的固有校正以及对B（1）不均匀性的进一步补偿。
