谷氨酸棒杆菌在对更易代谢的底物进行共代谢时对甲基内吸磷-S-甲基的还原裂解作用。
Reductive cleavage of demeton-S-methyl by Corynebacterium glutamicum in cometabolism on more readily metabolizable substrates.
作者信息
Girbal L, Hilaire D, Leduc S, Delery L, Rols J L, Lindley N D
机构信息
Laboratoire de Biotechnologie-Bioprocédés, UMR CNRS 5504 and UMR INRA 792, Centre de Bioingénierie Gilbert Durand, INSA, 31077 Toulouse cedex 4, France.
出版信息
Appl Environ Microbiol. 2000 Mar;66(3):1202-4. doi: 10.1128/AEM.66.3.1202-1204.2000.
Abstract
Corynebacterium glutamicum is able to biotransform demeton-S-methyl, an organophosphorus compound, during cometabolism with more readily metabolizable substrates. Among the cosubstrates used, fructose is the growth substrate that is most favorable for demeton-S-methyl biotransformation. The reaction mechanism of demeton-S-methyl biotransformation involves reductive cleavage of an S-C bond, which leads to accumulation of dimethyl thiophosphate in the culture medium.
摘要
谷氨酸棒杆菌能够在与更易代谢的底物共代谢过程中对有机磷化合物甲基内吸磷进行生物转化。在所使用的共底物中，果糖是最有利于甲基内吸磷生物转化的生长底物。甲基内吸磷生物转化的反应机制涉及S-C键的还原裂解，这导致培养基中磷酸二甲酯的积累。
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