Oermann C M, Panesar K S, Langston C, Larsen G L, Menendez A A, Schofield D E, Cosio C, Fan L L
Departments of Pediatrics and Pathology, Baylor College of Medicine, Houston, TX, USA.
J Pediatr. 2000 Mar;136(3):351-8. doi: 10.1067/mpd.2000.103350.
Pulmonary infiltrates with eosinophilia (PIE) are a group of heterogeneous disorders having the common findings of lung disease and eosinophilia in the peripheral blood, bronchoalveolar lavage fluid, or pulmonary interstitium. Eleven cases of PIE syndromes were identified through a retrospective and prospective chart review: drug-induced (2), acute eosinophilic pneumonia (3), infant pulmonary eosinophilia (2), parasite-induced (2), Churg-Strauss syndrome (1), and atypical chronic PIE (1). Patient demographics, clinical presentation, and disease severity varied considerably among groups. Therapeutic interventions included bronchodilators (10), oxygen (7), corticosteroids (9), and mechanical ventilation (3). A single patient with acute eosinophilic pneumonia died. Our experience suggests that PIE syndromes are rare in childhood and that clinical presentation can vary widely. Because of the potential for significant morbidity and mortality, aggressive diagnostic evaluations are warranted, particularly in children with respiratory failure of unknown etiology.
伴有嗜酸性粒细胞增多的肺部浸润（PIE）是一组异质性疾病，其共同特点是肺部疾病以及外周血、支气管肺泡灌洗液或肺间质中嗜酸性粒细胞增多。通过回顾性和前瞻性病历审查确定了11例PIE综合征病例：药物性（2例）、急性嗜酸性粒细胞性肺炎（3例）、婴儿肺嗜酸性粒细胞增多症（2例）、寄生虫性（2例）、变应性肉芽肿性血管炎（1例）和非典型慢性PIE（1例）。各亚组患者的人口统计学特征、临床表现和疾病严重程度差异很大。治疗措施包括支气管扩张剂（10例）、吸氧（7例）、皮质类固醇（9例）和机械通气（3例）。1例急性嗜酸性粒细胞性肺炎患者死亡。我们的经验表明，PIE综合征在儿童中罕见，临床表现差异很大。鉴于其有导致严重发病和死亡的可能性，有必要进行积极的诊断评估，尤其是对于病因不明的呼吸衰竭儿童。
