Rojo-Martínez G, Soriguer F J, González-Romero S, Tinahones F, Moreno F, de Adana S R, Garriga M J, Esteva I, García-Arnés J, Gómez-Zumaquero J M, García-Almeida J M
Endocrinology and Nutrition Service, Clinical-Experimental Investigation Unit, 'Carlos Haya' Regional Hospital, Málaga, Spain.
Eur J Endocrinol. 2000 Mar;142(3):263-8. doi: 10.1530/eje.0.1420263.
To study the contribution of a normal intake of nutrients to the variability of serum leptin concentrations in persons with type 1 diabetes mellitus.
We studied the relation between serum leptin and nutrient intake in a cross-sectional study.
Serum leptin measured by radioimmunoassay, nutritional data determined by a self-administered 7-day nutritional questionnaire, and the fatty acid composition of the serum phospholipids (measured by thin layer chromatography and gas chromatography) were determined in 60 patients with type 1 diabetes mellitus. Correlation and regression analyses were performed between serum leptin and dietary fatty acids and serum phospholipid fatty acids.
In the prediction models for the concentrations of serum leptin in men with type 1 diabetes mellitus, the dietary fatty acids displaced the anthropometric variables, and were independent of the serum testosterone concentrations. This fact remained when the prediction was made on the basis of indirect markers of the intake, such as the serum phospholipid fatty acids. In the women, the fatty acids from the diet or from the serum phospholipids also partly explained the variation in serum leptin, although not displacing the anthropometric variables.
Our data suggest that, in non-experimental conditions, the concentrations of serum leptin in men with type 1 diabetes mellitus and, to a lesser extent, those in women with diabetes, may be influenced by the composition of the habitual diet, especially the type of dietary fat.
研究正常营养摄入对1型糖尿病患者血清瘦素浓度变异性的影响。
我们在一项横断面研究中探讨了血清瘦素与营养摄入之间的关系。
对60例1型糖尿病患者测定了通过放射免疫分析法测得的血清瘦素、通过自行填写的7天营养调查问卷确定的营养数据以及血清磷脂的脂肪酸组成（通过薄层色谱法和气相色谱法测定）。对血清瘦素与膳食脂肪酸以及血清磷脂脂肪酸进行了相关性和回归分析。
在1型糖尿病男性患者血清瘦素浓度的预测模型中，膳食脂肪酸取代了人体测量学变量，且独立于血清睾酮浓度。基于摄入量的间接标志物（如血清磷脂脂肪酸）进行预测时，这一情况依然存在。在女性患者中，膳食或血清磷脂中的脂肪酸也部分解释了血清瘦素的变化，尽管并未取代人体测量学变量。
我们的数据表明，在非实验条件下, 1型糖尿病男性患者的血清瘦素浓度，以及在较小程度上糖尿病女性患者的血清瘦素浓度，可能受日常饮食组成的影响，尤其是膳食脂肪的类型。
