Institute of Public Health, University of Porto, Porto, Portugal.
1] Institute of Public Health, University of Porto, Porto, Portugal [2] Department of Clinical Epidemiology, Predictive Medicine and Public Health and Cardiovascular Research and Development Unit, University of Porto Medical School, Porto, Portugal.
Eur J Clin Nutr. 2014 May;68(5):555-60. doi: 10.1038/ejcn.2014.36. Epub 2014 Mar 19.
BACKGROUND/OBJECTIVES: Evidence on the association between fatty acids and adiponectin and leptin concentrations is scarce and inconsistent, which may in part be due to limitations of dietary reporting methods. We aimed to estimate the association of fatty acids, derived from a food frequency questionnaire (FFQ) and measured in the erythrocyte membrane, with adiponectin and leptin concentrations.
SUBJECTS/METHODS: We studied 330 non-institutionalized inhabitants of Porto (52.4% women; age range: 26-64 years) evaluated in 2010-2011, as part of the EPIPorto cohort study. Fatty acids were derived from a validated semiquantitative FFQ and measured in the erythrocyte membrane by gas chromatography. Serum concentrations of adiponectin and leptin were determined through radioimmunoassay. Regression coefficients (β) and 95% confidence intervals (95% CI) were obtained from linear regression models, after controlling for gender, age, education, leisure time physical activity and total body fat percentage (obtained from dual energy X-ray absorptiometry).
Fatty acids measured by FFQ showed no significant associations with both adipokines. Lauric and linoleic acids, measured in the erythrocyte membrane, were significantly and positively associated with adiponectin (β=0.292, 95% CI: 0.168-0.416; β=0.150, 95% CI: 0.020-0.280) and leptin (β=0.071, 95% CI: 0.003-0.138; β=0.071, 95% CI: 0.002-0.140), whereas total n-3, eicosapentaenoic and docosahexaenoic acids were significantly but negatively associated with adiponectin (β=-0.289, 95% CI: -0.420 to -0.159; β=-0.174, 95% CI -0.307 to -0.040; β=-0.253, 95% CI -0.383 to -0.124) and leptin (β=-0.151, 95% CI: -0.220 to -0.083; β=-0.080, 95% CI: -0.151 to -0.009; β=-0.146, 95% CI: -0.214 to -0.078). Positive significant associations of palmitic and trans-fatty acids with adiponectin were also observed.
A positive association of lauric and linoleic acids and a negative association of total n-3 fatty acids with both adipokines were observed only with fatty acids measured in the erythrocyte membrane.
背景/目的：关于脂肪酸与脂联素和瘦素浓度之间的关联的证据很少且不一致，这可能部分归因于饮食报告方法的局限性。我们旨在评估源自食物频率问卷（FFQ）并在红细胞膜中测量的脂肪酸与脂联素和瘦素浓度之间的关联。
研究对象/方法：我们研究了 2010-2011 年作为 Porto EPIPorto 队列研究一部分的 330 名非机构居民（52.4%为女性；年龄范围：26-64 岁）。脂肪酸源自经过验证的半定量 FFQ，并通过气相色谱法在红细胞膜中测量。通过放射免疫测定法测定血清脂联素和瘦素浓度。在控制性别、年龄、教育程度、休闲时间体育活动和全身脂肪百分比（通过双能 X 射线吸收法获得）后，从线性回归模型中获得回归系数（β）和 95%置信区间（95%CI）。
FFQ 测量的脂肪酸与两种脂联素有无显著关联。红细胞膜中测量的月桂酸和亚油酸与脂联素呈显著正相关（β=0.292，95%CI：0.168-0.416；β=0.150，95%CI：0.020-0.280）和瘦素（β=0.071，95%CI：0.003-0.138；β=0.071，95%CI：0.002-0.140），而总 n-3、二十碳五烯酸和二十二碳六烯酸与脂联素呈显著负相关（β=-0.289，95%CI：-0.420 至-0.159；β=-0.174，95%CI-0.307 至-0.040；β=-0.253，95%CI-0.383 至-0.124）和瘦素（β=-0.151，95%CI：-0.220 至-0.083；β=-0.080，95%CI：-0.151 至-0.009；β=-0.146，95%CI：-0.214 至-0.078）。还观察到棕榈酸和反式脂肪酸与脂联素的正显著关联。
仅在红细胞膜中测量脂肪酸时，观察到月桂酸和亚油酸与脂联素呈正相关，而总 n-3 脂肪酸与脂联素和瘦素均呈负相关。
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