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1
The destructive action of IL-1alpha and IL-1beta in IDDM is a multistage process: evidence and confirmation by apoptotic studies, induction of intermediates and electron microscopy.白细胞介素-1α和白细胞介素-1β在胰岛素依赖型糖尿病中的破坏作用是一个多阶段过程：凋亡研究的证据与证实、中间体的诱导及电子显微镜观察。
Mediators Inflamm. 1999;8(2):85-91. doi: 10.1080/09629359990577.
2
IL-1 beta transduces different signals than IL-1 alpha leading to class II antigen expression on beta-insulinoma RIN-5AH cells through specific receptors.与IL-1α相比，IL-1β通过特定受体转导不同信号，从而导致β-胰岛素瘤RIN-5AH细胞上的II类抗原表达。
J Recept Signal Transduct Res. 1997 Jan-May;17(1-3):211-25. doi: 10.3109/10799899709036605.
3
STAT5 activation by human GH protects insulin-producing cells against interleukin-1beta, interferon-gamma and tumour necrosis factor-alpha-induced apoptosis independent of nitric oxide production.人生长激素激活信号转导子和转录激活子5可保护胰岛素生成细胞免受白细胞介素-1β、干扰素-γ和肿瘤坏死因子-α诱导的细胞凋亡，且不依赖于一氧化氮的产生。
J Endocrinol. 2005 Oct;187(1):25-36. doi: 10.1677/joe.1.06086.
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Myricetin inhibits the induction of anti-Fas IgM-, tumor necrosis factor-alpha- and interleukin-1beta-mediated apoptosis by Fas pathway inhibition in human osteoblastic cell line MG-63.杨梅素通过抑制人成骨细胞系MG-63中的Fas途径，抑制抗Fas IgM、肿瘤坏死因子-α和白细胞介素-1β介导的凋亡诱导。
Life Sci. 2005 Oct 21;77(23):2964-76. doi: 10.1016/j.lfs.2005.05.026.
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Protective effect of Coptidis Rhizoma on S-nitroso-N-acetylpenicillamine (SNAP)-induced apoptosis and necrosis in pancreatic RINm5F cells.
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A biphasic role of nuclear transcription factor (NF)-kappaB in the islet beta-cell apoptosis induced by interleukin (IL)-1beta.核转录因子（NF）-κB在白细胞介素（IL）-1β诱导的胰岛β细胞凋亡中的双相作用。
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[Interleukin-1 and nitric oxide involved in the pathogenesis of diabetes)].[白细胞介素-1和一氧化氮参与糖尿病发病机制]
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Fraxetin inhibits the induction of anti-Fas IgM, tumor necrosis factor-alpha and interleukin-1beta-mediated apoptosis by Fas pathway inhibition in human osteoblastic cell line MG-63.秦皮素通过抑制人成骨细胞系MG-63中的Fas途径，抑制抗Fas IgM、肿瘤坏死因子-α和白细胞介素-1β介导的凋亡诱导。
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Localization and expression of CCR3 and CCR5 by interleukin-1 beta in the RIN-5AH insulin-producing model system: a protective mechanism involving down-regulation of chemokine receptors.
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Cytokines activate caspase-3 in insulinoma cells of diabetes-prone NOD mice directly and via upregulation of Fas.细胞因子可直接激活易患糖尿病的非肥胖糖尿病（NOD）小鼠胰岛素瘤细胞中的半胱天冬酶-3，并通过上调Fas来激活。
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The novel association between red complex of oral microbe and body mass index in healthy Japanese: a population based cross-sectional study.健康日本人群中口腔微生物红色复合体与体重指数之间的新型关联：一项基于人群的横断面研究。
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Endoplasmic reticulum stress is increased in adipose tissue of women with gestational diabetes.妊娠糖尿病女性的脂肪组织中内质网应激增加。
PLoS One. 2015 Apr 7;10(4):e0122633. doi: 10.1371/journal.pone.0122633. eCollection 2015.
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Inducible HSP70 antagonizes IL-1β cytocidal effects through inhibiting NF-kB activation via destabilizing TAK1 in HeLa cells.诱导型 HSP70 通过使 TAK1 不稳定来抑制 NF-κB 活化，从而拮抗 HeLa 细胞中 IL-1β 的细胞毒性作用。
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Insulin-like growth factor binding protein-3 is a novel mediator of apoptosis in insulin-secreting cells.胰岛素样生长因子结合蛋白-3是胰岛素分泌细胞中一种新型的细胞凋亡介质。
Growth Horm IGF Res. 2004 Jun;14(3):216-25. doi: 10.1016/j.ghir.2003.12.009.
6
Changes in expression of IL-1 beta influenced proteins in transplanted islets during development of diabetes in diabetes-prone BB rats.在糖尿病易感性BB大鼠糖尿病发展过程中，白细胞介素-1β影响蛋白在移植胰岛中的表达变化。
Diabetologia. 2004 May;47(5):892-908. doi: 10.1007/s00125-004-1382-y. Epub 2004 Apr 23.

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Apoptosis and the pathogenesis of IDDM: a question of life and death.细胞凋亡与胰岛素依赖型糖尿病的发病机制：生与死的问题。
Diabetes. 1998 Oct;47(10):1537-43. doi: 10.2337/diabetes.47.10.1537.
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Protein kinase C regulates Fas (CD95/APO-1) expression.蛋白激酶C调节Fas（CD95/APO-1）的表达。
J Immunol. 1998 Sep 1;161(5):2201-7.
3
The 40-kDa subunit of DNA fragmentation factor induces DNA fragmentation and chromatin condensation during apoptosis.DNA片段化因子的40 kDa亚基在细胞凋亡过程中诱导DNA片段化和染色质浓缩。
Proc Natl Acad Sci U S A. 1998 Jul 21;95(15):8461-6. doi: 10.1073/pnas.95.15.8461.
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[Apoptosis of HL-60 cells induced by Harringtonine: membrane blebs, nucleus blebs and chromatin condensation].高三尖杉酯碱诱导HL-60细胞凋亡：膜泡、核泡及染色质凝聚
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Apoptosis: identification of dying cells.
Cell Biol Toxicol. 1998 Mar;14(2):111-20. doi: 10.1023/a:1007429904664.
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Nitric oxide primes pancreatic beta cells for Fas-mediated destruction in insulin-dependent diabetes mellitus.一氧化氮使胰腺β细胞对胰岛素依赖型糖尿病中Fas介导的破坏作用更为敏感。
J Exp Med. 1997 Oct 20;186(8):1193-200. doi: 10.1084/jem.186.8.1193.
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The role of Fas in autoimmune diabetes.Fas在自身免疫性糖尿病中的作用。
Cell. 1997 Apr 4;89(1):17-24. doi: 10.1016/s0092-8674(00)80178-6.
8
Cell death mediators in autoimmune diabetes--no shortage of suspects.自身免疫性糖尿病中的细胞死亡介质——不乏可疑对象。
Cell. 1997 Apr 4;89(1):1-3. doi: 10.1016/s0092-8674(00)80174-9.
9
IL-1 beta transduces different signals than IL-1 alpha leading to class II antigen expression on beta-insulinoma RIN-5AH cells through specific receptors.与IL-1α相比，IL-1β通过特定受体转导不同信号，从而导致β-胰岛素瘤RIN-5AH细胞上的II类抗原表达。
J Recept Signal Transduct Res. 1997 Jan-May;17(1-3):211-25. doi: 10.3109/10799899709036605.
10
The role of interleukin-1 in the pathogenesis of IDDM.白细胞介素-1在胰岛素依赖型糖尿病发病机制中的作用。
Diabetologia. 1996 Sep;39(9):1005-29. doi: 10.1007/BF00400649.

白细胞介素-1α和白细胞介素-1β在胰岛素依赖型糖尿病中的破坏作用是一个多阶段过程：凋亡研究的证据与证实、中间体的诱导及电子显微镜观察。

The destructive action of IL-1alpha and IL-1beta in IDDM is a multistage process: evidence and confirmation by apoptotic studies, induction of intermediates and electron microscopy.

作者信息

Vassiliadis S, Dragiotis V, Protopapadakis E, Athanassakis I, Mitlianga P, Konidaris K, Papadopoulos G K

机构信息

Department of Biology, University of Crete, Greece.

出版信息

Mediators Inflamm. 1999;8(2):85-91. doi: 10.1080/09629359990577.

DOI:10.1080/09629359990577
PMID:10704145
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1781784/
Abstract

Using the rat beta-cell RIN-5AH insulinoma line as a means for studying insulin-dependent diabetes mellitus (IDDM), it is shown that interleukin-1 (IL-1) induces beta-cell damage initiated by early apoptotic signals. This action is demonstrated by DNA fragmentation, as assessed by specific BrdU labeling, surface expression of Fas and nitric oxide (NO) production. In addition, the interplay between NO and Fas is shown, while scanning electron microscopy (SEM) confirms apoptosis by revealing the degree and type of cellular damage which, in the case of IL-1alpha, can be reversed by an inhibitor to NO synthesis. Apoptosis is also reconfirmed by transmission electron microscopy (TEM) by observing condensed nuclear chromatin after IL-1 exposure. Thus, treatment of insulinoma cells with IL-1alpha and IL-1beta seems to initiate a number of signals, including PKC activation as published previously, that ultimately lead to beta-cell destruction. Each IL-1 isoform, however, definitely follows a different pathway of action.

摘要

利用大鼠β细胞RIN - 5AH胰岛素瘤细胞系作为研究胰岛素依赖型糖尿病（IDDM）的手段，研究表明白细胞介素-1（IL - 1）通过早期凋亡信号引发β细胞损伤。通过特异性BrdU标记评估的DNA片段化、Fas的表面表达和一氧化氮（NO）生成证明了这一作用。此外，还展示了NO与Fas之间的相互作用，而扫描电子显微镜（SEM）通过揭示细胞损伤的程度和类型证实了细胞凋亡，在IL - 1α的情况下，这种损伤可被NO合成抑制剂逆转。透射电子显微镜（TEM）通过观察IL - 1暴露后浓缩的核染色质也再次证实了细胞凋亡。因此，用IL - 1α和IL - 1β处理胰岛素瘤细胞似乎会引发许多信号，包括如先前报道的PKC激活，最终导致β细胞破坏。然而，每种IL - 1同工型肯定遵循不同的作用途径。