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Untying the Gordian knot of cytokinesis. Role of small G proteins and their regulators.

作者信息

Prokopenko S N, Saint R, Bellen H J

机构信息

Program in Developmental Biology, Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA.

出版信息

J Cell Biol. 2000 Mar 6;148(5):843-8. doi: 10.1083/jcb.148.5.843.

DOI:10.1083/jcb.148.5.843
PMID:10704435
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2174545/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/73cd/2174545/3cdc39b8cf23/JCB0001018.f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/73cd/2174545/c6d4eb24c71d/JCB0001018.f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/73cd/2174545/3cdc39b8cf23/JCB0001018.f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/73cd/2174545/c6d4eb24c71d/JCB0001018.f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/73cd/2174545/3cdc39b8cf23/JCB0001018.f2.jpg

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本文引用的文献

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Neuron. 2000 Feb;25(2):307-16. doi: 10.1016/s0896-6273(00)80896-x.
2
Human ECT2 is an exchange factor for Rho GTPases, phosphorylated in G2/M phases, and involved in cytokinesis.人ECT2是一种Rho GTP酶交换因子,在G2/M期被磷酸化,并参与胞质分裂。
J Cell Biol. 1999 Nov 29;147(5):921-8. doi: 10.1083/jcb.147.5.921.
3
Four-dimensional control of the cell cycle.
细胞中肌动蛋白细胞骨架动力学的调节。
Mol Cells. 2010 Apr;29(4):311-25. doi: 10.1007/s10059-010-0053-8.
4
p190RhoGAP negatively regulates Rho activity at the cleavage furrow of mitotic cells.p190RhoGAP在有丝分裂细胞的分裂沟处对Rho活性起负调控作用。
Exp Cell Res. 2009 May 1;315(8):1347-59. doi: 10.1016/j.yexcr.2009.02.014. Epub 2009 Feb 27.
5
Parallel chemical genetic and genome-wide RNAi screens identify cytokinesis inhibitors and targets.平行化学遗传学和全基因组RNA干扰筛选鉴定胞质分裂抑制剂和靶点。
PLoS Biol. 2004 Dec;2(12):e379. doi: 10.1371/journal.pbio.0020379. Epub 2004 Oct 5.
6
Terminal cytokinesis events uncovered after an RNAi screen.RNA干扰筛选后发现的末期胞质分裂事件。
Curr Biol. 2004 Sep 21;14(18):1685-93. doi: 10.1016/j.cub.2004.08.063.
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Mol Biol Cell. 2004 Nov;15(11):5053-63. doi: 10.1091/mbc.e04-06-0536. Epub 2004 Sep 15.
8
Mutations in sticky lead to defective organization of the contractile ring during cytokinesis and are enhanced by Rho and suppressed by Rac.“sticky”基因的突变会导致细胞分裂过程中收缩环的组织缺陷,且这种缺陷会被Rho增强,被Rac抑制。
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