Khare N, Fascetti N, DaRocha S, Chiquet-Ehrismann R, Baumgartner S
Department of Cell & Molecular Biology, Box 94, Lund University, S-22100, Lund, Sweden.
Mech Dev. 2000 Mar 1;91(1-2):393-7. doi: 10.1016/s0925-4773(99)00297-x.
We report the sequence and expression analysis of two new Drosophila members of the Semaphorin family. Both proteins show the presence of Semaphorin domains and transmembrane domains. Both genes are expressed maternally and in embryos, and reveal distinct expression patterns much earlier than the onset of neurogenesis. We also present an overview of the domain structure of all so far known semaphorins in Drosophila. Furthermore, we compared all Drosophila and C. elegans Semaphorins and discuss them in the light of their evolution.
我们报告了信号素家族两个新的果蝇成员的序列和表达分析。两种蛋白质均显示存在信号素结构域和跨膜结构域。两个基因在母体和胚胎中均有表达，并且在神经发生开始之前就显示出明显不同的表达模式。我们还概述了果蝇中所有已知信号素的结构域结构。此外，我们比较了所有果蝇和秀丽隐杆线虫的信号素，并根据它们的进化情况进行了讨论。
