Zhang Yueyi, Shi Hanfen, Dai Xuan, Shen Jin, Yin Jiyuan, Xu Tianshu, Yue Gaiyue, Guo Haochen, Liang Ruiqiong, Chen Qishuang, Gao Sihua, Wang Lili, Zhang Dongwei
Traditional Chinese Medicine School, Diabetes Research Center, Beijing University of Chinese Medicine, Beijing, 100029, China.
Department of TCM Pharmacology, Chinese Material Medica School, Beijing University of Chinese Medicine, Beijing, 102488, China.
Calcif Tissue Int. 2025 Feb 22;116(1):43. doi: 10.1007/s00223-025-01350-4.
Semaphorin 3A (Sema3A) is a signaling protein that has attracted increasing attention in recent years for its important role in regulating bone metabolism. In this review, we searched different databases with various combinations of keywords to analyze the effects of Sema3A on osteoporosis. Sema3A promotes bone formation and inhibits bone resorption by directly affecting the osteoblast and osteoclast or indirectly targeting the nervous system. The sympathetic nervous system may be the main link between the central nervous system and bone metabolism for Sema3A. In the peripheral nervous system, Sema3A may improve bone quality via sensory nervous innervation. In addition, estrogen is found to regulate Sema3A levels to improve bone homeostasis. Lots of Sema3A agonists have been documented to exhibit anti-osteoporotic potential in preclinical investigations. Therefore, Sema3A can be considered a novel therapeutic target for preserving bone mass, highlighting an alternative strategy for the development of anti-osteoporosis drugs.
信号素3A（Sema3A）是一种信号蛋白，近年来因其在调节骨代谢中的重要作用而受到越来越多的关注。在本综述中，我们用各种关键词组合搜索了不同的数据库，以分析Sema3A对骨质疏松症的影响。Sema3A通过直接影响成骨细胞和破骨细胞或间接作用于神经系统来促进骨形成并抑制骨吸收。交感神经系统可能是Sema3A在中枢神经系统和骨代谢之间的主要联系环节。在周围神经系统中，Sema3A可能通过感觉神经支配来改善骨质量。此外，发现雌激素可调节Sema3A水平以改善骨稳态。许多Sema3A激动剂在临床前研究中已被证明具有抗骨质疏松的潜力。因此，Sema3A可被视为一种用于维持骨量的新型治疗靶点，为抗骨质疏松药物的开发突出了一种替代策略。
