Le Dévéhat C, Khodabandehlou T, Vimeux M
Unité de Recherches d'Hémorhéologie Clinique et de Microcirculation, Nevers, France.
J Mal Vasc. 2000 Feb;25(1):53-7.
Fibrinogen level, erythrocyte aggregation and transcutaneous oxygen pressure (TcPO2) were measured in the two populations of 32 healthy volunteer subjects and 119 diabetic patients without any clinical sign of micro and/or macroangiopathy. Measured parameters were studied according to both the long term glycemic control (HbA1C) and the type of diabetes. Results showed a significant elevation of plasma fibrinogen in all diabetic patients even when they had good glycemic control. Hyperfibrinogenemia appeared to be related to both long term glycemic control and type of diabetes. Hyperfibrinogenemia in studied diabetic patients was associated with a tendency to erythrocyte hyperaggregation. Indeed, this hyperaggregation like fibrinogen level, seem to be related to both HbA1C level and the type of diabetes. In contrast, the TcPO2 was found to be significantly decreased in all patients irrespective to either HbA1C or the type of diabetes. Besides, TcPO2 was not correlated with fibrinogen nor erythrocyte aggregation. In conclusion, the decrease in TcPO2 as observed here, does not directly depend upon the type of diabetes, or the HbA1C level, i.e the quality of mid and/or long term glycemic control.
在32名健康志愿者和119名无任何微血管和/或大血管病变临床症状的糖尿病患者这两组人群中，测量了纤维蛋白原水平、红细胞聚集和经皮氧分压（TcPO2）。根据长期血糖控制情况（糖化血红蛋白HbA1C）和糖尿病类型对测量参数进行了研究。结果显示，即使血糖控制良好，所有糖尿病患者的血浆纤维蛋白原水平仍显著升高。高纤维蛋白原血症似乎与长期血糖控制和糖尿病类型均有关。所研究的糖尿病患者中的高纤维蛋白原血症与红细胞过度聚集的倾向有关。实际上，这种过度聚集与纤维蛋白原水平一样，似乎与HbA1C水平和糖尿病类型均有关。相比之下，发现所有患者的TcPO2均显著降低，无论其HbA1C水平或糖尿病类型如何。此外，TcPO2与纤维蛋白原及红细胞聚集均无相关性。总之，此处观察到的TcPO2降低并不直接取决于糖尿病类型或HbA1C水平，即中、长期血糖控制质量。
