Khodabandehlou T, Le Devehat C
Unité de Recherches d'Hémorhéologie Clinique, Centre hospitalier, Nevers.
J Mal Vasc. 1994;19(3):190-4.
To better understand the abnormalities of red blood cell (RBC) hyperaggregation and elevation of fibrinogen during diabetes mellitus, we have studied the effect of plasminogen activation on RBC aggregation phenomenon. The plasminogen was activated in vitro by adding streptokinase in blood suspensions of 26 diabetic patients and 11 healthy subjects. RBC aggregation measurements were performed by means of the Sefam erythroaggregometer. Results show decreases in either RBC aggregation and fibrinogen level as a result of the plasminogen activation in blood suspensions of healthy subjects. In blood suspensions of diabetic patients, although RBC aggregation and fibrinogen level are decreased following the plasminogen activation, however decreases are less pronounced than those obtained in blood suspensions of healthy subjects. These results mean a decreased degradation of fibrinogen by plasmin in diabetes mellitus and could explain in part the excess of fibrinogen and so the hyperaggregation tendency of red blood cells.
为了更好地理解糖尿病期间红细胞（RBC）过度聚集和纤维蛋白原升高的异常情况，我们研究了纤溶酶原激活对红细胞聚集现象的影响。通过在26例糖尿病患者和11例健康受试者的血液悬液中添加链激酶，在体外激活纤溶酶原。使用Sefam红细胞聚集仪进行红细胞聚集测量。结果显示，健康受试者血液悬液中的纤溶酶原激活导致红细胞聚集和纤维蛋白原水平降低。在糖尿病患者的血液悬液中，虽然纤溶酶原激活后红细胞聚集和纤维蛋白原水平降低，但降低程度不如健康受试者血液悬液中明显。这些结果意味着糖尿病患者中纤溶酶对纤维蛋白原的降解减少，这可以部分解释纤维蛋白原的过量以及红细胞的过度聚集倾向。
