Le Devehat C, Khodabandehlou T, Vimeux M
Unité de Recherches d'Hémorhéologie Clinique, Centre Hospitalier, Nevers, France.
Diabete Metab. 1994 Jul-Aug;20(4):401-4.
From numerous studies, it is now well known that diabetes mellitus is usually accompanied by miscellaneous hemorheological disturbances. These may alter the microcirculatory flow and lead ultimately to tissue chronic hypoxia. In this report, red blood cell aggregation characteristics and transcutaneous oxygen pressure (TcPO2) have been evaluated in diabetic patients without any sign of angiopathy. Results showed a tendency towards erythrocyte hyperaggregation in diabetic patients, even when under good glycaemic control. TcPO2 measurements, were found to be significantly lower in diabetic patients than in control subjects. Furthermore, the TcPO2 values were related with the aggregation parameters, confirming thereby the existence of an inter-relationship and thus the possible role played by hemorheological parameters in oxygen transport to tissues and hence in the pathogenesis of microangiopathy at the functional level.
从众多研究中可知，糖尿病通常伴有多种血液流变学紊乱。这些紊乱可能会改变微循环血流，并最终导致组织慢性缺氧。在本报告中，对无任何血管病变迹象的糖尿病患者的红细胞聚集特性和经皮氧分压（TcPO2）进行了评估。结果显示，即使血糖控制良好，糖尿病患者仍有红细胞过度聚集的倾向。发现糖尿病患者的TcPO2测量值显著低于对照组。此外，TcPO2值与聚集参数相关，从而证实了它们之间存在相互关系，进而证实了血液流变学参数在向组织输送氧气中可能发挥的作用，以及在功能层面微血管病变发病机制中的作用。
