Claus J J, Ongerboer De Visser B W, Bour L J, Walstra G J, Hijdra A, Verbeeten B, Van Royen E A, Kwa V I, van Gool W A
Department of Neurology, Academic Medical Center, University of Amsterdam, The Netherlands.
Dement Geriatr Cogn Disord. 2000 Mar-Apr;11(2):81-9. doi: 10.1159/000017219.
Electroencephalography (EEG) bands may have different clinical or physiological correlates at initial diagnosis of Alzheimer's disease (AD). We studied 163 consecutive patients with probable (n = 105) and possible (n = 58) AD with measurements of cognitive function (CAMCOG), regional cerebral blood flow (rCBF) with single photon emission computed tomography using technetium-99m-labeled hexamethylpropylene amine oxime, and computed tomography (CT). Lower CAMCOG scores were significantly and most strongly associated with lower parieto-occipital and fronto-central alpha power. In a separate analysis of cognitive domains, disturbances in language, praxis, attention, and abstraction were also significantly and most consistently related to decrease in alpha power. Presence of cortical atrophy as measured on CT showed some statistically significant relations with EEG bands, but these associations were not consistent. Lower temporal and parietal rCBF were significantly related to lower parieto-occipital alpha activity. Presence of leukoaraiosis was significantly associated with lower beta values, but also with higher absolute theta and delta activity. The results suggest that alpha on EEG is most closely linked to cognitive function and rCBF, while beta and theta activity more likely reflect lower cortical or subcortical changes. Our study thus provides evidence that the EEG bands reflect differential pathophysiologic changes in AD.
在阿尔茨海默病（AD）初诊时，脑电图（EEG）频段可能具有不同的临床或生理相关性。我们对163例连续性可能（n = 105）和疑似（n = 58）AD患者进行了研究，测量了其认知功能（CAMCOG）、使用锝-99m标记的六甲丙二胺肟通过单光子发射计算机断层扫描测量的局部脑血流量（rCBF）以及计算机断层扫描（CT）。较低的CAMCOG评分与较低的顶枕叶和额中央α波功率显著且最为强烈地相关。在对认知领域的单独分析中，语言、运用、注意力和抽象能力的障碍也与α波功率降低显著且最为一致地相关。CT测量的皮质萎缩的存在与EEG频段显示出一些统计学上的显著关系，但这些关联并不一致。较低的颞叶和顶叶rCBF与较低的顶枕叶α活动显著相关。白质疏松的存在与较低的β值显著相关，但也与较高的绝对θ波和δ波活动相关。结果表明，EEG上的α波与认知功能和rCBF联系最为紧密，而β波和θ波活动更可能反映较低级别的皮质或皮质下变化。因此，我们的研究提供了证据表明EEG频段反映了AD中不同的病理生理变化。
