Wyper D, Teasdale E, Patterson J, Montaldi D, Brown D, Hunter R, Graham D, McCulloch J
Department of Clinical Physics, Southern General Hospital, Glasgow, UK.
Br J Radiol. 1993 Jan;66(781):23-7. doi: 10.1259/0007-1285-66-781-23.
The pattern of abnormal distribution of the single photon emission computed tomography (SPECT) cerebral blood flow tracer 99m-technetium-hexamethylpropyleneamine oxime (99Tcm-HMPAO) was investigated in 14 patients with clinically diagnosed Alzheimer's disease (AD) who subsequently had post-mortem confirmation of the disease and also in 14 elderly control subjects. These abnormalities were compared with computed tomography (CT) scans to investigate the degree to which the focal SPECT deficits were due to atrophy. The results show that SPECT imaging with 99Tcm-HMPAO and CT scanning both have a higher incidence of abnormality in AD patients than in controls and that the difference between patients and controls is greater with SPECT than with CT. Frontal SPECT and CT abnormalities in moderate/severe Alzheimer's disease occur as frequently as temporal/occipital abnormalities but the latter are rare in control subjects. Around 50% of the SPECT deficits occur in CT normal brain regions, showing that atrophy is not the sole cause of SPECT deficits.
在14例临床诊断为阿尔茨海默病（AD）且随后经尸检确诊的患者以及14名老年对照受试者中，研究了单光子发射计算机断层扫描（SPECT）脑血流示踪剂99m-锝-六甲基丙烯胺肟（99Tcm-HMPAO）的异常分布模式。将这些异常与计算机断层扫描（CT）进行比较，以研究局灶性SPECT缺陷在多大程度上是由萎缩引起的。结果表明，与对照组相比，AD患者中使用99Tcm-HMPAO进行SPECT成像和CT扫描的异常发生率均更高，且患者与对照组之间SPECT的差异大于CT。中度/重度阿尔茨海默病患者的额叶SPECT和CT异常与颞叶/枕叶异常出现的频率相同，但后者在对照受试者中很少见。约50%的SPECT缺陷出现在CT正常的脑区，表明萎缩不是SPECT缺陷的唯一原因。
