Thomas-Antérion C, Jacquin K, Laurent B
Service de Neurologie, Hôpital Bellevue, Saint-Etienne, France.
Dement Geriatr Cogn Disord. 2000 Mar-Apr;11(2):100-6. doi: 10.1159/000017221.
This paper describes retrograde memory performances of 12 Alzheimer's disease (AD) patients and 12 frontotemporal dementia (FTD) patients. First of all, we observed that FTD and AD patients did not differ for language tests (verbal fluency tests and oral denomination 80), for semantic memory tests, for logical memory test and Benton visual memory test and differed for anterograde verbal memory and frontal tests. Concerning retrograde memory, there was no difference between AD and FTD patients in retrograde memory scores (autobiographical memory interview, Crovitz's task, French public events interview battery) and both FTD and AD patients exhibited a retrieval deficit in their remote memory. We observed that the mechanisms of remote memory deficit was different in FTD and in AD patients. We observed no classical paradigm of Ribot for FTD patient's remote informations, and they appeared to have lost of access to memories and executive difficulties. In AD, the results indicated these patients' ability to learn new information and to search semantic memory failed.
本文描述了12名阿尔茨海默病（AD）患者和12名额颞叶痴呆（FTD）患者的逆行记忆表现。首先，我们观察到FTD和AD患者在语言测试（言语流畅性测试和口语命名80）、语义记忆测试、逻辑记忆测试和本顿视觉记忆测试方面没有差异，而在顺行言语记忆和额叶测试方面存在差异。关于逆行记忆，AD和FTD患者在逆行记忆分数（自传体记忆访谈、克罗维茨任务、法国公共事件访谈量表）上没有差异，并且FTD和AD患者在其远期记忆中均表现出提取缺陷。我们观察到FTD和AD患者远期记忆缺陷的机制不同。我们没有观察到FTD患者远期信息的经典里博范式，他们似乎失去了对记忆的提取能力并且存在执行困难。在AD中，结果表明这些患者学习新信息和搜索语义记忆的能力受损。
