Taché Y, Taché J, Mécs I, Du Ruisseau P, Selye H
J Med. 1976;7(6):471-9.
In rats, PCN (the most potent catatoxic steroid known to date) at the usual dose level powerfully inhibited the toxicity of antazoline, carbamazepine, cocaine, guanethidine, ibuprofen, ketamine, LSD, nembutal and reserpine, whereas (except in the case of nembutal) thyroxine sensitized the animals to intoxication with these same compounds. Even much lower doses of PCN or thyroxine exerted similar but weaker effects. PCN-induced resistance to the various substrates was generally not altered by concurrent administration of thyroxine but in a few cases its protective action was partially or totally inhibited, depending upon the respective dose levels of both compounds.
在大鼠中，苯丙酸诺龙（PCN，迄今为止已知的最有效的抗毒性甾体）在通常剂量水平下能有效抑制安他唑啉、卡马西平、可卡因、胍乙啶、布洛芬、氯胺酮、麦角酸二乙酰胺（LSD）、戊巴比妥和利血平的毒性，而（除戊巴比妥外）甲状腺素会使动物对这些相同化合物的中毒更加敏感。即使是更低剂量的苯丙酸诺龙或甲状腺素也会产生类似但较弱的效果。苯丙酸诺龙诱导的对各种底物的抗性通常不会因同时给予甲状腺素而改变，但在少数情况下，其保护作用会部分或完全受到抑制，这取决于两种化合物各自的剂量水平。
