Anğ-Küçüker M, Büyükbaba-Boral O, Tolun V, Törümküney D, Susever S, Anğ O
Department of Microbiology, Istanbul Medical Faculty, Capa.
Zentralbl Bakteriol. 2000 Jan;289(8):781-5. doi: 10.1016/s0934-8840(00)80001-8.
Serratia marcescens is characterized by its ability to produce a red pigment called prodigiosin. It is well known that there are some substances affecting pigmentation in bacteria. Cefoxitin, erythromycin, tobramycin, co-trimoxazole, imipenem and nitrofurantoin were found to have an inhibitory effect on pigmentation in a S. marcescens strain isolated from urine. It was also shown that the LD50 dose determined by inoculation of eight-week-old BALB/c mice with serial dilutions of overnight cultures of pigmented and nonpigmented variants was lower (LD50 = 300 x 10(3.94)) in the nonpigmented variant than in the pigmented one (LD50 = 300 x 10(5.58)). In addition, the Sereny test showed that in contrast to the pigmented variant, the nonpigmented variant caused keratitis in guinea pig eye.
粘质沙雷氏菌的特点是能够产生一种名为灵菌红素的红色色素。众所周知，有一些物质会影响细菌的色素沉着。在从尿液中分离出的一株粘质沙雷氏菌中，发现头孢西丁、红霉素、妥布霉素、复方新诺明、亚胺培南和呋喃妥因对色素沉着有抑制作用。研究还表明，通过用色素沉着和无色素变体的过夜培养物的系列稀释液接种八周龄的BALB/c小鼠来确定的半数致死剂量，无色素变体（LD50 = 300×10(3.94)）比色素沉着变体（LD50 = 300×10(5.58)）更低。此外，角膜结膜试验表明，与色素沉着变体相比，无色素变体在豚鼠眼中引起了角膜炎。
