Piotrowski P, Gajkowska B, Olszewska H, Smiałek M
Department of Neuropathology, Polish Academy of Sciences, Warszawa.
Folia Neuropathol. 1999;37(4):256-63.
Male Wistar rats were subjected to streptozotocin administration (85 mg/kg i.p.) and to cerebral air embolia with common carotids ligation. Electron microscope studies showed dark neurons, degeneration of endothelial cells and changes in basement membrane of brain capillaries, and changed astroglia in diabetic rats. Our results seem to support our previous findings in light microscopy and correspond with some others authors' suggestions that diabetes leads to chronic, generalized pathologic process in diabetic-rat brain, not-only dependent on vascular pathology, but which may be related to an oxidative/metabolic stress leading to a death of neurons in necrotic or apoptotic way.
雄性Wistar大鼠接受链脲佐菌素注射（腹腔注射，85毫克/千克）并通过结扎颈总动脉造成脑空气栓塞。电子显微镜研究显示，糖尿病大鼠存在深色神经元、内皮细胞变性、脑毛细血管基底膜改变以及星形胶质细胞变化。我们的结果似乎支持我们之前在光学显微镜下的发现，并与其他一些作者的观点一致，即糖尿病会导致糖尿病大鼠大脑发生慢性、全身性病理过程，这不仅取决于血管病变，还可能与导致神经元以坏死或凋亡方式死亡的氧化/代谢应激有关。
