Wu W, Kuang P, Zhu K
Neurotransmitter Research Laboratory, Chinese PLA General Hospital, Postgraduate Military Medical School, Beijing.
J Tradit Chin Med. 1992 Sep;12(3):183-6.
The effect of RSM on ultrastructural alterations of the cortical, hippocampal and caudate neucleus areas brought about by forebrain ischemia in rats were studied. In both RSM-treated and saline-treated groups the ischemic damage was detected in nearly all animals three hours after bilateral common carotid artery ligation, while it was much more mild in RSM-treated animals. The ultrastructural changes consisted of swollen mitochondria, partial loss of cristae, dilatation of rough endoplasmic reticulum and Golgi's complex. In addition, some dark neurons were present, capillary endothelial cells and processes of astrocytes were swollen and active pinocytosis appeared in the endothelial cells. Their presence was most severe in the hippocampus region and the least in the caudate nuclear area. No ultrastructural changes exhibited in the sham-operated animals. The findings of the present experiment demonstrate that RSM can reduce ultrastructural abnormalities of cerebral ischemia and are also direct evidence of the protective effect of RSM on cerebral ischemia.
研究了红景天苷（RSM）对大鼠前脑缺血所致皮质、海马和尾状核区域超微结构改变的影响。在RSM治疗组和生理盐水治疗组中，几乎所有动物在双侧颈总动脉结扎3小时后均检测到缺血损伤，但RSM治疗组动物的损伤要轻得多。超微结构变化包括线粒体肿胀、嵴部分丢失、粗面内质网和高尔基体扩张。此外，还存在一些深色神经元，毛细血管内皮细胞和星形胶质细胞的突起肿胀，内皮细胞出现活跃的胞饮作用。它们在海马区最为严重，在尾状核区最少。假手术动物未表现出超微结构变化。本实验结果表明，RSM可减轻脑缺血的超微结构异常，也是RSM对脑缺血具有保护作用的直接证据。
