0.5%马来酸噻吗洛尔、2%盐酸卡替洛尔和0.3%美替洛尔对眼压和视野检查结果的影响比较及其眼内和全身效应评估

Comparison of the effects of 0.5% timolol maleate, 2% carteolol hydrochloride, and 0.3% metipranolol on intraocular pressure and perimetry findings and evaluation of their ocular and systemic effects.

作者信息

Mirza G E, Karaküçük S, Temel E

机构信息

Department of Ophthalmology, Erciyes University Faculty of Medicine, Kayseri, Turkey.

出版信息

J Glaucoma. 2000 Feb;9(1):45-50. doi: 10.1097/00061198-200002000-00009.

DOI:10.1097/00061198-200002000-00009

PMID:10708231

Abstract

PURPOSE

To compare the effects of 0.5% timolol maleate, 2% carteolol, and 0.3% metipranolol on intraocular pressure (IOP) in 45 patients with primary open-angle glaucoma (POAG) and ocular hypertension. A secondary goal of this study was to evaluate the ocular and systemic side effects of these medications.

METHODS

Measurements of IOP were taken at baseline (pretreatment) and 2, 6, and 12 hours after instillation on treatment days 15, 30, 60, and 90. Mean sensitivity (MS) and mean defect (MD) values of perimetry before and after treatment and the effects of the three beta blockers on serum lipid profiles were determined. Ocular and systemic side effects were recorded.

RESULTS

The most prominent IOP lowering effect was noted with metipranolol at 2 and 6 hours on day 15, and with timolol maleate at 12 hours on day 15 and at all hours of the subsequent days on which measurements were taken. Timolol maleate produced a significant decrease in IOP at 12 hours on day 15 compared with carteolol. There was not a statistically significant difference between the MS and MD values on perimetry before and after treatment for any treatment. There was a statistically significant decrease in levels of total cholesterol and high-density lipoprotein (HDL) cholesterol and a significant increase in triglyceride levels; these changes were observed for all treatments.

CONCLUSION

The effects of the three medications were not statistically different from each other in terms of IOP reduction and visual field changes. Careful monitoring of blood lipid levels is necessary with long-term treatment with beta blockers, because these agents reduced serum levels of HDL and total cholesterol while increasing triglycerides. Such changes in lipid levels could lead to increased incidence of complications, particularly in patients with atherosclerosis or coronary heart disease.

摘要

目的

比较0.5%马来酸噻吗洛尔、2%卡替洛尔和0.3%美替洛尔对45例原发性开角型青光眼（POAG）和高眼压症患者眼压（IOP）的影响。本研究的次要目的是评估这些药物的眼部和全身副作用。

方法

在第15、30、60和90天治疗日滴眼后2、6和12小时以及基线（治疗前）测量眼压。测定治疗前后视野的平均敏感度（MS）和平均缺损（MD）值以及三种β受体阻滞剂对血脂谱的影响。记录眼部和全身副作用。

结果

在第15天的2小时和6小时，美替洛尔降低眼压的效果最显著；在第15天的12小时以及随后测量眼压的所有时间点，马来酸噻吗洛尔降低眼压的效果最显著。与卡替洛尔相比，马来酸噻吗洛尔在第15天的12小时使眼压显著降低。任何一种治疗的治疗前后视野MS和MD值之间均无统计学显著差异。所有治疗均观察到总胆固醇和高密度脂蛋白（HDL）胆固醇水平有统计学显著降低，甘油三酯水平有显著升高。