Sevastikoglou J A, Larsson S E
Acta Chir Scand Suppl. 1976;467:9-15.
Below-knee amputation in adult male rats resulted in characteristic quantitative and qualitative changes of the tibia stump and of the femur in the amputated leg. These changes were followed for periods of 1 to 32 weeks after the amputation. The femur of the amputated leg underwent a significant reduction of its total bone mass and a significant decrease of its percentage ash content, whereas its percentage water and organic contents increased significantly. The bone specific activity was initially decreased and began to increase after the 10th week post surgery with a positive linear regression. The amputated tibia underwent a significant, though declining, increase of its percentage water and organic contents and a likewise significant decrease of its percentage ash content. The specific activity of the amputated tibia was significantly higher than that of the tibia from the non-amputated leg, the difference showing a negative linear regression. The specific activity of the femur was decreased initially and increased later on.
成年雄性大鼠的膝下截肢导致截肢腿的胫骨残端和股骨出现特征性的定量和定性变化。截肢后1至32周对这些变化进行跟踪观察。截肢腿的股骨其总骨量显著减少，灰分含量百分比显著降低，而水分和有机成分百分比则显著增加。骨比活性最初降低，术后第10周开始增加，呈正线性回归。截肢的胫骨其水分和有机成分百分比显著增加，尽管呈下降趋势，其灰分含量百分比同样显著降低。截肢胫骨的比活性显著高于未截肢腿的胫骨，差异呈负线性回归。股骨的比活性最初降低，后来增加。
