Parent M B, Gold P E
Department of Psychology, University of Virginia, Charlottesville 22903, USA.
Brain Res. 1997 Jan 16;745(1-2):317-20. doi: 10.1016/s0006-8993(96)01206-1.
This experiment examined the effects of co-infusions of glucose with the gamma-aminobutyric acid (GABA) agonist muscimol into the medial septum on memory for inhibitory avoidance learning. Co-infusions of muscimol (3 nmol) and glucose (33 nmol) impaired memory, but neither drug did so when administered alone. Thus, although glucose typically reverses memory deficits, these results indicate that glucose potentiates the memory-impairing effects of a GABA agonist.
本实验研究了将葡萄糖与γ-氨基丁酸（GABA）激动剂蝇蕈醇共同注入内侧隔区对抑制性回避学习记忆的影响。蝇蕈醇（3纳摩尔）和葡萄糖（33纳摩尔）共同注入会损害记忆，但单独使用这两种药物时均不会如此。因此，尽管葡萄糖通常能逆转记忆缺陷，但这些结果表明，葡萄糖会增强GABA激动剂的记忆损害作用。
