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[心肌细胞基因组活性作为中枢神经系统暴露于电磁场后心肌适应性变化发展指标的研究]

[Activity of the genome of cardiomyocytes as an indicator of the development of adaptive changes in the myocardium following exposure of the central nervous system to electromagnetic fields].

作者信息

Zubkova S M, Mikhaĭlik L V, Varakina N I, Strukova E V, Bobkova A S

机构信息

Russian Scientific Centre of Rehabilitating Medicine and Health Resort Cure, Moscow.

出版信息

Tsitologiia. 2000;42(1):92-5.

PMID:10709259
Abstract

Methods of cardiomyocyte nuclei isolation from the myocard homogeneous mixture, and of cardiomyocyte genome activity estimation were elaborated. In the experiments with hyperlipoproteidemic rats, cardiomyocyte genome activity was shown to reflect the primary adaptive changes in the myocard, and to serve a reliable index of their influence on the CNS regulatory centres exposed to electromagnetic field, which is used for hyperlipoproteidemia treatment. The cardiomyocyte genome activity was used to distinguish between three types of development of adaptive reactions in the myocard.

摘要

阐述了从心肌匀浆中分离心肌细胞核的方法以及心肌细胞基因组活性评估方法。在高脂血症大鼠实验中,心肌细胞基因组活性被证明可反映心肌的原发性适应性变化,并作为其对暴露于电磁场的中枢神经系统调节中心影响的可靠指标,该电磁场用于高脂血症治疗。心肌细胞基因组活性被用于区分心肌适应性反应发展的三种类型。

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