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正常人血清中针对人白血病细胞的细胞毒性抗体。

Cytotoxic antibodies to human leukaemia cells in normal human sera.

作者信息

Dore J F, Guibout C, Bertoglio J, Liabeuf A

出版信息

Biomedicine. 1976 Dec 30;25(10):382-4.

PMID:1071010
Abstract

Antibodies cytotoxic for human leukaemia cells were demonstrated in the serum of normal individuals: two of them being the fathers of leukaemia children, the third one being a normal unrelated donor. One of these sera (obtained from the father of an eight years old girl with acute myeloblastic leukaemia) appears to react widely with cells from acute leukaemias, both lymphoid and myeloid. On the other hand, the serum obtained from the normal blood donor appears to react almost exclusively with cells from acute lymphoblastic leukaemias, and more especially with those which do not form rosettes with sheep red cells.

摘要

在正常个体的血清中发现了对人白血病细胞具有细胞毒性的抗体

其中两人是白血病患儿的父亲,第三人是正常的无关供体。其中一份血清(来自一名患有急性髓细胞白血病的8岁女孩的父亲)似乎与急性白血病的细胞广泛反应,包括淋巴细胞性和髓细胞性白血病细胞。另一方面,从正常献血者获得的血清似乎几乎只与急性淋巴细胞白血病的细胞反应,尤其是与那些不与绵羊红细胞形成玫瑰花结的细胞反应。

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