Chen L Y, Jokela R, Li D Y, Bavry A A, Sandler H, Sjöquist M, Saldeen T, Mehta J L
Department of Surgery, Forensic Medicine, University of Uppsala, Sweden.
J Cardiovasc Pharmacol. 2000 Mar;35(3):502-5. doi: 10.1097/00005344-200003000-00022.
We examined the influence of dietary stable fish oil on aortic thrombosis, platelet aggregation, and superoxide dismutase (SOD) activity in a rat model. Twenty-nine Sprague-Dawley rats were fed regular chow supplemented with stable fish oil preparation (for 1 or 3 weeks), and 37 rats fed regular chow served as controls. The abdominal cavity was opened, and the abdominal aorta isolated. Whatman paper impregnated with 35% FeCl3 was wrapped around the surface of the aorta, and aortic flow was continuously recorded. In control rats, an occlusive platelet-fibrin-rich thrombus was formed in 21 +/- 3 min. Dietary fish oil in a time-dependent fashion delayed time to thrombus formation (24 +/- 2 min in rats fed fish oil for 1 week and 31 +/- 2 min in rats fed fish oil for 3 weeks), inhibited platelet aggregation (21 +/- 5% vs. 45 +/- 6%; p < 0.01) and increased SOD activity (p < 0.01). We conclude that dietary supplementation with stable fish oil delays formation of arterial thrombus, probably by reducing platelet aggregation and oxidative stress-associated arterial injury.
我们在大鼠模型中研究了膳食稳定鱼油对主动脉血栓形成、血小板聚集和超氧化物歧化酶（SOD）活性的影响。29只Sprague-Dawley大鼠喂食添加了稳定鱼油制剂的普通饲料（持续1周或3周），37只喂食普通饲料的大鼠作为对照。打开腹腔，分离出腹主动脉。将浸有35% FeCl3的Whatman滤纸包裹在主动脉表面，并持续记录主动脉血流。在对照大鼠中，富含血小板-纤维蛋白的闭塞性血栓在21±3分钟内形成。膳食鱼油以时间依赖性方式延迟血栓形成时间（喂食鱼油1周的大鼠为24±2分钟，喂食鱼油3周的大鼠为31±2分钟），抑制血小板聚集（21±5%对45±6%；p<0.01）并增加SOD活性（p<0.01）。我们得出结论，膳食补充稳定鱼油可延迟动脉血栓形成，可能是通过减少血小板聚集和氧化应激相关的动脉损伤来实现的。
