Ecknauer R
Acta Hepatogastroenterol (Stuttg). 1976 Sep-Oct;23(5):365-71.
Six and twelve hours after a single i.p. dose of cyclophosphamide (100 mg/kg body weight) the activity of different "brush border enzymes" (maltase, sucrase lactase, alkaline phosphatase, gamma-glutamyl transferase) and of a lysosomal enzyme (acid phosphatase) did not change. In vivo absorption of galactose was not diminished by the treatment. The pattern of response to cyclophosphamide seems to be different in SPF and GF rats. The response of crypt epithelium (cell number, mitotic number, mitotic frequency) was more pronounced in the SPF rats, whereas the villus height only decreased in the GF rats.
单次腹腔注射环磷酰胺（100毫克/千克体重）后6小时和12小时，不同“刷状缘酶”（麦芽糖酶、蔗糖酶、乳糖酶、碱性磷酸酶、γ-谷氨酰转移酶）和一种溶酶体酶（酸性磷酸酶）的活性未发生变化。该处理并未降低半乳糖的体内吸收。无特定病原体（SPF）大鼠和无菌（GF）大鼠对环磷酰胺的反应模式似乎有所不同。隐窝上皮的反应（细胞数量、有丝分裂数量、有丝分裂频率）在SPF大鼠中更为明显，而绒毛高度仅在GF大鼠中降低。
