Bühler F R, Lütold B E, Küng M, Koller F J
Aust N Z J Med. 1976 Aug;6(3 Suppl):37-43. doi: 10.1111/j.1445-5994.1976.tb03333.x.
A single daily dose antihypertensive therapy with a new slow-release (SR) form of the beta-adrenoceptor blocking agent oxprenolol was as effective as a standard tid beta-blocker regimen in maintaining therapeutic effects over 24 hours. The good overall response rate (target larger than or equal to mmHg diastolic) of 67% was achieved in eight of the 11 high renin patients and 16 out of the 20 normal renin ones; the five low renin patients, who were also older, proved to be non-responsive. In terms of age, 83% of the patients aged under 40 years showed a reduction in diastolic pressure to larger than or equal to 95 mmHg, this percentage being significantly better than the 50% response rate in the 40--56-year-olds. In nine of the 12 beta-blocker non-responders the diastolic blood pressure was reduced to larger than 95 mmHg by adding a diuretic, and in four of the nine, all of them low renin patients, this effect persisted in response to diuretics alone. Oxprenolol SR suppresses renin acutely (59%) and chronically (62%), and it blunts the renin stimulatory effects of diuretics.
使用新型缓释（SR）剂型的β-肾上腺素受体阻滞剂氧烯洛尔进行每日一次的单剂量抗高血压治疗，在维持24小时的治疗效果方面与标准的每日三次β受体阻滞剂治疗方案同样有效。11例高肾素患者中的8例以及20例正常肾素患者中的16例达到了良好的总体缓解率（舒张压目标大于或等于 mmHg）；5例低肾素患者（年龄也较大）被证明无反应。在年龄方面，83%的40岁以下患者舒张压降至大于或等于95 mmHg，这一百分比显著高于40 - 56岁患者50%的缓解率。在12例β受体阻滞剂无反应者中，有9例通过加用利尿剂使舒张压降至大于95 mmHg，在这9例中的4例（均为低肾素患者），仅使用利尿剂时这种效果仍持续存在。氧烯洛尔缓释剂可急性（59%）和慢性（62%）抑制肾素，并且可减弱利尿剂对肾素的刺激作用。
