Klasen H J
University Hospital Groningen, Department of Surgery, The Netherlands.
Burns. 2000 Mar;26(2):131-8. doi: 10.1016/s0305-4179(99)00116-3.
In 1965, Moyer revived interest in silver nitrate solution. He concluded on the basis on in vitro and in vivo studies that a 0.5% solution represented the lowest concentration at which antibacterial action (against Staphylococcus aureus, haemolytic streptococci and generally against Pseudomonas aeruginosa and E. coli) was obtained. Mafenide acetate was introduced a short time after the reintroduction of silver nitrate, followed a few years later by silver sulphadiazine. Thus, in a short period of time three medicaments appeared on the market which represented a radical change in the topical treatment of burns. The action of silver sulphadiazine has been intensively studied. Since silver sulphadiazine does not offer sufficient protection to prevent or retard the growth of gram-negative bacteria in patients with burns covering more than 50% of body surface, Monafo introduced the combined preparation silver sulphadiazine and cerium nitrate. Although various attempts have been made to develop more effective silver compounds, so far silver sulphadiazine still remains the most widely used substance of this type.
1965年，莫耶重新引发了人们对硝酸银溶液的兴趣。他根据体外和体内研究得出结论，0.5%的溶液是获得抗菌作用（针对金黄色葡萄球菌、溶血性链球菌以及一般针对铜绿假单胞菌和大肠杆菌）的最低浓度。在重新引入硝酸银后不久，引入了醋酸磺胺米隆，几年后又引入了磺胺嘧啶银。因此，在短时间内，三种药物出现在市场上，这代表了烧伤局部治疗的根本性变化。磺胺嘧啶银的作用已得到深入研究。由于磺胺嘧啶银在烧伤面积超过体表面积50%的患者中，不能提供足够的保护来预防或延缓革兰氏阴性菌的生长，莫纳福推出了磺胺嘧啶银和硝酸铈的复方制剂。尽管人们进行了各种尝试来开发更有效的银化合物，但到目前为止，磺胺嘧啶银仍然是这类药物中使用最广泛的物质。
