Okada-Ban M, Thiery J P, Jouanneau J
Institut Curie, UMR 144/CNRS, Laboratory of Morphogenesis and Tumor Progression, Paris, France.
Int J Biochem Cell Biol. 2000 Mar;32(3):263-7. doi: 10.1016/s1357-2725(99)00133-8.
Fibroblast growth factor-2 (FGF-2) is a heparin-binding growth factor which occurs in several isoforms resulting from alternative initiations of translation: an 18 kD cytoplasmic isoform and four larger molecular weight nuclear isoforms (22, 22.5, 24 and 34 kD). FGF-2 has pleiotropic roles in many cell types and tissues; it is a motogenic, angiogenic and survival factor which is involved in cell migration, cell differentiation and in a variety of developmental processes. Although devoid of signal peptide, it could be secreted. It acts mainly through a paracrine/autocrine mechanism involving high affinity transmembrane receptors and heparan sulfate proteoglycan low affinity receptors, but also through still unknown intracrine process(es) on intracellular targets. FGF-2 has many biological functions which are probably isoform-specific. Nevertheless, FGF-2 is not essential for embryonic development as knock-out mice for the growth factor are viable and fertile although they exhibit abnormalities in neuronal differentiation. Use of FGF-2 as therapeutic agent for the treatment of ischemic cardiovascular disease is promising and clinical trials are in progress.
成纤维细胞生长因子-2（FGF-2）是一种肝素结合生长因子，它有几种因翻译起始位点不同而产生的异构体：一种18kD的细胞质异构体和四种分子量更大的核异构体（22、22.5、24和34kD）。FGF-2在许多细胞类型和组织中具有多效性作用；它是一种促有丝分裂、促血管生成和存活因子，参与细胞迁移、细胞分化以及多种发育过程。尽管它没有信号肽，但仍可分泌。它主要通过一种旁分泌/自分泌机制发挥作用，该机制涉及高亲和力跨膜受体和硫酸乙酰肝素蛋白聚糖低亲和力受体，不过也通过对细胞内靶点的仍未知的内分泌过程发挥作用。FGF-2有许多可能具有异构体特异性的生物学功能。然而，FGF-2对胚胎发育并非必不可少，因为该生长因子的基因敲除小鼠虽然在神经元分化方面表现出异常，但仍能存活且可育。将FGF-2用作治疗缺血性心血管疾病的治疗剂很有前景，相关临床试验正在进行中。
