Larson M R, Duberstein P R, Talbot N L, Caldwell C, Moynihan J A
Center for Psychoneuroimmunology Research, University of Rochester Medical Center, 300 Crittenden Boulevard, Rochester, NY 14642, USA.
J Psychosom Res. 2000 Feb;48(2):187-94. doi: 10.1016/s0022-3999(99)00110-5.
The present study evaluated the feasibility and potential immunological benefit of a presurgical intervention for breast cancer patients.
Forty-one newly diagnosed breast cancer patients were randomized into control (standard care) and intervention groups. In addition to standard care, intervention group members received a two-session psychosocial intervention. Blood was drawn at three timepoints: (1) at preintervention; (2) at postintervention/presurgery; and (3) at postsurgery.
Examination of the immunological data revealed evidence of suppression of interferon-gamma (IFN-gamma) in the control group over time, but not in the intervention group. Secondary findings related to psychological assessment generally paralleled the IFN-gamma results.
The relevance and applicability of these findings to future breast cancer intervention research is detailed.
本研究评估了乳腺癌患者术前干预的可行性和潜在免疫益处。
41名新诊断的乳腺癌患者被随机分为对照组（标准护理）和干预组。除标准护理外，干预组成员接受了两阶段的心理社会干预。在三个时间点采集血液：（1）干预前；（2）干预后/术前；（3）术后。
对免疫数据的检查显示，对照组中随着时间推移存在干扰素-γ（IFN-γ）受抑制的证据，而干预组则没有。与心理评估相关的次要发现总体上与IFN-γ结果平行。
详细阐述了这些发现与未来乳腺癌干预研究的相关性和适用性。
