Ohta Y, Kongo M, Sasaki E, Nishida K, Ishiguro I
Department of Biochemistry, School of Medicine, Fujita Health University, Aichi, Japan.
Adv Exp Med Biol. 1999;467:327-32. doi: 10.1007/978-1-4615-4709-9_42.
We examined the preventive effect of melatonin on the progression of carbon tetrachloride (CCl4)-induced acute liver injury in rats. In rats injected with CCl4 (1.0 ml/kg body weight), liver injury appeared 6 h after the injection and progressed at 24 h. This liver injury progression was prevented by treatment with melatonin (50 or 100 mg/kg body weight), which was conducted 6 h after CCl4 injection. An increase in liver lipid peroxide content and a decrease in liver reduced glutathione content occurred with the liver injury progression. These changes were prevented by the post-treatment of melatonin (50 or 100 mg/kg body weight). These results indicate that melatonin can prevent the progression of CCl4-induced acute liver injury through its antioxidant action.
我们研究了褪黑素对四氯化碳（CCl4）诱导的大鼠急性肝损伤进展的预防作用。在注射CCl4（1.0 ml/kg体重）的大鼠中，注射后6小时出现肝损伤，并在24小时时进展。在CCl4注射后6小时用褪黑素（50或100 mg/kg体重）治疗可预防这种肝损伤进展。随着肝损伤进展，肝脂质过氧化物含量增加，肝还原型谷胱甘肽含量降低。这些变化可通过褪黑素（50或100 mg/kg体重）的后期治疗来预防。这些结果表明，褪黑素可通过其抗氧化作用预防CCl4诱导的急性肝损伤进展。
