Biederman J, Rivinus T M, Herzog D B, Ferber R A, Harper G P, Orsulak P J, Harmatz J S, Schildkraut J J
Am J Psychiatry. 1984 Oct;141(10):1244-7. doi: 10.1176/ajp.141.10.1244.
Platelet MAO activity was determined in 33 anorexia nervosa patients. A subgroup of 15 patients who met Research Diagnostic Criteria for a concomitant major depressive disorder were found to have, both initially and after 5 weeks of treatment, significantly lower mean platelet monoamine oxidase (MAO) activity than 28 matched normal control subjects. In contrast, mean platelet MAO activity in the patients who did not meet criteria for major depressive disorder was similar to values in control subjects. The authors found that significantly more depressed patients had low MAO activity compared with nondepressed patients and controls. Platelet MAO activity may be useful in discriminating among subtypes of anorexia nervosa patients.
对33名神经性厌食症患者的血小板单胺氧化酶（MAO）活性进行了测定。15名符合伴有重度抑郁症研究诊断标准的患者亚组，在治疗初期和治疗5周后，其平均血小板单胺氧化酶（MAO）活性均显著低于28名匹配的正常对照受试者。相比之下，不符合重度抑郁症标准的患者的平均血小板MAO活性与对照受试者的值相似。作者发现，与非抑郁患者和对照组相比，抑郁患者中MAO活性低的明显更多。血小板MAO活性可能有助于区分神经性厌食症患者的亚型。
