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[一例与氯气中毒相关的肺血栓栓塞症尸检病例]

[An autopsy case of pulmonary thromboembolism associated with chlorine gas poisoning].

作者信息

Asano M, Nushida H, Ueno Y, Yata K, Adachi J, Tatsuno Y

机构信息

Department of Legal Medicine, Kobe University School of Medicine, Japan.

出版信息

Nihon Hoigaku Zasshi. 1999 Nov;53(3):345-9.

Abstract

We report a rare case of sudden death of a patient with acute pulmonary thromboembolism associated with chlorine gas poisoning. A 21-year-old man in a water-filtration plant accidentally inhaled highly concentrated chlorine gas. He was immediately brought to a hospital after exposure. On admission, the patient had clouding of consciousness, dyspnea, and deep cyanosis. Arterial blood gas values indicated severe hypoxemia; PaO2 was 35.9 mmHg and PaCO2 was 42.4 mmHg. The clinical course was uneventful and he was satisfactorily recovering. However, ten days after admission he became sick and markedly cyanotic. He lost consciousness and then he went into cardiopulmonary arrest. Despite efforts at resuscitation, he died. An autopsy revealed bilateral pulmonary thromboembolism, although he apparently did not have any risk factor for embolism. The toxicity of chlorine gas may be related to the pulmonary thromboembolism, but the mechanisms leading to his death are unclear.

摘要

我们报告了一例急性肺血栓栓塞症合并氯气中毒患者猝死的罕见病例。一名21岁的男子在一家滤水厂意外吸入高浓度氯气。接触氯气后他立即被送往医院。入院时,患者意识模糊、呼吸困难且伴有严重发绀。动脉血气值显示严重低氧血症;动脉血氧分压(PaO2)为35.9 mmHg,动脉血二氧化碳分压(PaCO2)为42.4 mmHg。临床过程平稳,他恢复良好。然而,入院十天后,他病情加重,出现明显发绀。他失去意识,随后发生心肺骤停。尽管进行了复苏努力,但他最终死亡。尸检显示双侧肺血栓栓塞,尽管他显然没有任何栓塞的危险因素。氯气的毒性可能与肺血栓栓塞有关,但导致他死亡的机制尚不清楚。

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