Kivivuori S M, Pelkonen P, Ylijoki H, Verronen P, Siimes M A
Hospital for Children and Adolescents, University of Helsinki, Helsinki, Rheumatism Foundation Hospital, Heinola, Finland.
Rheumatology (Oxford). 2000 Feb;39(2):193-7. doi: 10.1093/rheumatology/39.2.193.
Active juvenile chronic arthritis (JCA) is accompanied by anaemia of chronic disease, which may be indistinguishable from anaemia due to iron deficiency. We speculate that elevation of the serum transferrin receptor (sTfR) concentration, which should not be influenced by inflammation, would be useful for detecting the role of iron status in anaemic children with JCA.
sTfR concentrations were measured in 30 children with JCA.
The median sTfR was elevated, 6.1 (range 3.4-13.0) mg/l. In 13 patients (43%) the concentrations exceeded the upper limit for healthy subjects. Haemoglobin (r = - 0.48, P = 0.008), mean corpuscular volume (r = - 0.47, P = 0.009) and mean corpuscular haemoglobin (r = - 0.65, P = 0.0001) correlated inversely with sTfR concentration.
In 13 of the 30 patients with JCA, the sTfR concentration, which is an indicator of iron status and erythropoiesis, was elevated. The results raise the possibility that sTfR is able to distinguish iron-deficiency anaemia from anaemia of chronic disease. It should be further explored as a candidate.
活动期青少年慢性关节炎（JCA）伴有慢性病性贫血，这可能与缺铁性贫血难以区分。我们推测血清转铁蛋白受体（sTfR）浓度升高不受炎症影响，有助于检测铁状态在JCA贫血儿童中的作用。
对30例JCA患儿测定sTfR浓度。
sTfR中位数升高，为6.1（范围3.4 - 13.0）mg/l。13例患者（43%）的浓度超过健康受试者上限。血红蛋白（r = - 0.48，P = 0.008）、平均红细胞体积（r = - 0.47，P = 0.009）和平均红细胞血红蛋白（r = - 0.65，P = 0.0001）与sTfR浓度呈负相关。
30例JCA患者中有13例sTfR浓度升高，sTfR是铁状态和红细胞生成的指标。结果提示sTfR有可能区分缺铁性贫血和慢性病性贫血。应将其作为一个候选指标进一步研究。
