Bumann D, Hueck C, Aebischer T, Meyer T F
Max-Planck-Institut für Infektionsbiologie, Abt. Molekulare Biologie, Monbijoustrasse 2, D-10117, Berlin, Germany.
FEMS Immunol Med Microbiol. 2000 Apr;27(4):357-64. doi: 10.1111/j.1574-695X.2000.tb01450.x.
Live attenuated Salmonella spp. are promising candidates as oral vaccine delivery systems for heterologous antigens. Clinical trials have demonstrated that this approach is feasible for human vaccinations but further optimisation is necessary to obtain a better efficacy. Here, we discuss how existing clinical and pre-clinical data can be used to guide such optimisation efforts.
减毒活沙门氏菌作为异源抗原的口服疫苗递送系统是很有前景的候选者。临床试验表明，这种方法用于人类疫苗接种是可行的，但需要进一步优化以获得更好的疗效。在此，我们讨论如何利用现有的临床和临床前数据来指导此类优化工作。
