Galen J E, Levine M M
Center for Vaccine Development, University of Maryland School of Medicine, 685 W. Baltimore St, Baltimore, MD 21201, USA.
Trends Microbiol. 2001 Aug;9(8):372-6. doi: 10.1016/s0966-842x(01)02096-0.
The efficiency of any live bacterial vector vaccine hinges on its ability to present sufficient foreign antigen to the human immune system to initiate the desired protective immune response(s). However, synthesis of sufficient levels of heterologous antigen can result in an increase in metabolic burden with an accompanying decrease in the fitness of the live vector, which can ultimately lower desired immune responses to both live vector and heterologous antigen. Here, we explore the underlying mechanisms of metabolic load and propose ways of minimizing such burdens to enhance the fitness and immunogenicity of Salmonella-based live vector vaccines.
任何活细菌载体疫苗的效率都取决于其向人类免疫系统呈递足够的外源抗原以引发所需保护性免疫反应的能力。然而，合成足够水平的异源抗原会导致代谢负担增加，同时活载体的适应性下降，这最终可能降低对活载体和异源抗原的预期免疫反应。在此，我们探讨代谢负荷的潜在机制，并提出将此类负担降至最低的方法，以提高基于沙门氏菌的活载体疫苗的适应性和免疫原性。
