Lippens R J, van Ooijen A G
Center for Pediatric Oncology South East Netherlands, University Hospital Nijmegen, The Netherlands.
Eur J Paediatr Neurol. 1997;1(2-3):85-9. doi: 10.1016/s1090-3798(97)80068-2.
Calcifications in the basal ganglia have been found in nine (5.4%) of all children treated for any kind of brain tumour in our department. This has occurred over a mean period of 2.8 years after diagnosis. The group of patients has been compared with a group of other children, matched for age, sex, histologic diagnosis and tumour treatment, but without calcifications of the basal ganglia. The groups differ from each other with respect to a significantly higher incidence of hypothyroidism and growth hormone deficiency in the group of children with calcifications in the basal ganglia. Moreover the children with calcifications show a larger IQ-loss. Although the pathogenesis of the calcifications of the basal ganglia is not known, an association of damage to the vascular bed of the basal ganglia due to periods of increased intracranial pressure, together with endocrine deficiencies is discussed. We advise an adequate supplementation in cases of endocrine deficiencies in children treated for brain tumours as early as possible.
在我们科室接受过任何类型脑肿瘤治疗的所有儿童中，有9名（5.4%）被发现基底节区存在钙化。这一情况发生在诊断后的平均2.8年期间。已将该组患者与另一组年龄、性别、组织学诊断和肿瘤治疗情况相匹配但基底节区无钙化的儿童进行了比较。基底节区有钙化的儿童组与另一组相比，甲状腺功能减退和生长激素缺乏的发生率显著更高。此外，有钙化的儿童智商损失更大。尽管基底节区钙化的发病机制尚不清楚，但讨论了由于颅内压升高期导致基底节区血管床受损以及内分泌缺乏之间的关联。我们建议，对于接受脑肿瘤治疗的儿童，一旦出现内分泌缺乏，应尽早进行适当补充。
