O'Connor L, Harris A W, Strasser A
The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.
Cancer Res. 2000 Mar 1;60(5):1217-20.
The tumor suppressor p53 exerts its antioncogenic effects in cells chiefly by regulating their progression through the cell cycle and by inducing cell death. It has been claimed that p53-transduced apoptosis involves the death receptor CD95 (Fas/APO-1). We report that thymocytes from mice lacking functional Fas ligand (gld) show normal sensitivity to apoptosis transduced by p53, and that hepatocytes fromp53-/- mice have normal sensitivity to apoptosis triggered through ligation of CD95. p53 and CD95, therefore, function in independent pathways to cell death in these diverse cell types.
肿瘤抑制因子p53主要通过调节细胞周期进程和诱导细胞死亡在细胞中发挥其抗癌作用。有人声称p53介导的细胞凋亡涉及死亡受体CD95（Fas/APO-1）。我们报告，缺乏功能性Fas配体（gld）的小鼠胸腺细胞对p53介导的细胞凋亡表现出正常的敏感性，并且p53基因敲除小鼠的肝细胞对通过CD95连接引发的细胞凋亡具有正常的敏感性。因此，在这些不同的细胞类型中，p53和CD95在细胞死亡的独立途径中发挥作用。
