Kobrine A I, Evans D E, Rizzoli H V
J Neurosurg. 1979 May;50(5):639-44. doi: 10.3171/jns.1979.50.5.0639.
In this experiment, the effects of ischemia on neural conduction in the monkey spinal cord were studied. In six monkeys generalized ischemia of the spinal cord was created by bleeding the animals to a hypotensive level below the lower limits of autoregulation in the spinal cord. The progressive development of spinal cord ischemia was documented by blood-flow measurement using the hydrogen clearance method. Physiological integrity of the spinal cord was monitored and recorded by the spinal evoked response. The spinal evoked response did not disappear until at least 10 minutes of profound ischemia. At levels of ischemia 20% to 25% of normal blood flow, the spinal evoked response was unchanged. It is concluded that long-tract neural conduction in the spinal cord is relatively resistant to the effects of ischemia.
在本实验中，研究了缺血对猴脊髓神经传导的影响。对六只猴子，通过将动物放血至低于脊髓自身调节下限的低血压水平，造成脊髓广泛性缺血。采用氢清除法通过血流量测量记录脊髓缺血的进展情况。通过脊髓诱发反应监测并记录脊髓的生理完整性。在至少10分钟的深度缺血后脊髓诱发反应才消失。在缺血程度为正常血流量的20%至25%时，脊髓诱发反应未发生变化。得出的结论是，脊髓中的长束神经传导对缺血影响具有相对抗性。
