Rooney M, Massey K L, Jamali F, Rosin M, Thomson D, Johnson D H
Department of Anaesthesia, University of Saskatchewan, Saskatoon, Canada.
J Clin Pharmacol. 1996 Aug;36(8):760-3. doi: 10.1002/j.1552-4604.1996.tb04247.x.
A case involving a 27-year-old woman who ingested an overdose of acebutolol is presented. Extracorporeal membrane oxygenation was initiated to stabilize the patient's condition before commencing hemodialysis. S-diacetolol (the N-acetelation product of acebutolol) was cleared with hemodialysis. It is suggested that extracorporeal membrane oxygenation may be of short-term benefit in the treatment of overdoses with beta-adrenergic agents such as acebutolol when accelerated clearance with hemodialysis is anticipated.
本文报告了一例27岁女性过量服用醋丁洛尔的病例。在开始血液透析之前，启动了体外膜肺氧合以稳定患者的病情。血液透析清除了S-二醋洛尔（醋丁洛尔的N-乙酰化产物）。提示当预期通过血液透析加速清除时，体外膜肺氧合在治疗醋丁洛尔等β-肾上腺素能药物过量时可能具有短期益处。
