Fukuda M, Fukuda K, Yding Andersen C, Byskov A G
Fukuda Ladies Clinic, Ako, Japan.
Fertil Steril. 2000 Apr;73(4):742-7. doi: 10.1016/s0015-0282(99)00631-7.
To compare IVF and pregnancy outcomes before and after anovulation induced by oral contraceptives.
Observational clinical study.
Infertility clinic.
PATIENT(S): Forty women with two intact ovaries (32 of 40 couples with male factor infertility and 8 with unknown causes of infertility) underwent 190 IVF treatment cycles (55 natural cycles and 135 clomiphene citrate-stimulated cycles).
INTERVENTION(S): If the women failed to conceive after 2-4 IVF treatment cycles, oral contraceptives were used to induce anovulation for 1 month before IVF was performed in two consecutive cycles.
MAIN OUTCOME MEASURE(S): Rates of oocyte retrieval, fertilization, cleavage, preembryo formation, pregnancy, and implantation were compared before and after a period of anovulation.
RESULT(S): The pregnancy rate per cycle of the first and second cycle combined (23%) and that of the second cycle alone (30%) after a period of anovulation were significantly higher than that observed before a period of anovulation (9%).
CONCLUSION(S): Anovulation induced by oral contraceptives, showing bilateral ovarian quiescence, enhances pregnancy rates in the following two menstrual cycles of IVF treatment.
比较口服避孕药诱导无排卵前后的体外受精（IVF）及妊娠结局。
观察性临床研究。
不孕不育诊所。
40名双侧卵巢功能正常的女性（40对夫妇中32对男方因素不育，8对病因不明）接受了190个IVF治疗周期（55个自然周期和135个枸橼酸氯米芬刺激周期）。
若女性在2 - 4个IVF治疗周期后仍未受孕，则在连续两个IVF周期前使用口服避孕药诱导无排卵1个月。
比较无排卵前后的取卵率、受精率、卵裂率、胚胎前期形成率、妊娠率和着床率。
无排卵一段时间后，第一和第二周期合并的每个周期妊娠率（23%）以及仅第二周期的妊娠率（30%）显著高于无排卵前观察到的妊娠率（9%）。
口服避孕药诱导的无排卵，表现为双侧卵巢静止，可提高IVF治疗随后两个月经周期的妊娠率。
