Maekawa T, Ishii T
Department of Transfusion Medicine and Cell Therapy, The Institute of Medical Science, The University of Tokyo.
Intern Med. 2000 Feb;39(2):90-100. doi: 10.2169/internalmedicine.39.90.
Recently, a close association between hematopoiesis and chemokines and their receptors has been demonstrated. Much attention has been focused on the regulation of hematopoiesis by chemokines, because of the possibility of direct consequence for clinical practice in cell therapies such as hematopoietic stem cell transplantation. This report reviews the physiological roles of chemokines and their receptors in the context of hematopoietic cell regulation, with particular focus on the involvement of stromal cell derived factor (SDF)-1/pre-B cell growth stimulating factor (PBSF) and its receptor CXCR4. The proliferation, differentiation, migration, and engraftment of hematopoietic stem cells are discussed, and thereby raise a number of unresolved problems and points-to-consider.
最近，造血作用与趋化因子及其受体之间的密切关联已得到证实。由于趋化因子对诸如造血干细胞移植等细胞治疗临床实践可能产生直接影响，因此其对造血作用的调节已备受关注。本报告回顾了趋化因子及其受体在造血细胞调节方面的生理作用，尤其着重于基质细胞衍生因子（SDF）-1/前B细胞生长刺激因子（PBSF）及其受体CXCR4的作用。文中讨论了造血干细胞的增殖、分化、迁移和植入情况，进而提出了一些尚未解决的问题和需要考虑的要点。
