Humanitas Clinical and Research Center, via Manzoni 56, 20089 Rozzano (MI), Italy.
Humanitas Clinical and Research Center, via Manzoni 56, 20089 Rozzano (MI), Italy; Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini, 20090 Pieve Emanuele (MI), Italy.
Cytokine. 2018 Sep;109:76-80. doi: 10.1016/j.cyto.2018.01.021.
Although chemokines are best known for their role in directing cell migration, accumulating evidence indicate their involvement in many other processes. This review focus on the role of chemokines in hematopoiesis with an emphasis on myelopoiesis. Indeed, many chemokine family members are an important component of the cytokine network present in the bone marrow that controls proliferation, retention, and mobilization of hematopoietic progenitors.
虽然趋化因子以其在指导细胞迁移中的作用而闻名，但越来越多的证据表明它们还参与许多其他过程。本文重点介绍趋化因子在造血中的作用，特别是在骨髓生成中的作用。事实上，许多趋化因子家族成员是控制造血祖细胞增殖、保留和动员的骨髓中细胞因子网络的重要组成部分。
