Schuurman A G, Goldbohm R A, Dorant E, van den Brandt P A
Department of Epidemiology, Maastricht University, The Netherlands.
Am J Epidemiol. 2000 Mar 15;151(6):541-9. doi: 10.1093/oxfordjournals.aje.a010241.
In the Netherlands Cohort Study, the authors investigated whether anthropometry is associated with prostate cancer risk. At baseline in 1986, 58,279 men aged 55-69 years completed a self-administered questionnaire on diet, anthropometry, and other risk factors for cancer. After 6.3 years of follow-up, 681 cases were available with complete data on height and weight at baseline, and for 523 cases, there were data for weight at age 20 years. In both age-adjusted and multivariate case-cohort analyses (adjusted for age, family history of prostate cancer, and socioeconomic status), height, body mass index (BMI; kg/m2), and lean body mass (kg) at baseline were not associated with prostate cancer risk. The rate ratios of prostate cancer for men with a BMI at age 20 of less than 19, 19-20.9, 21-22.9, 23-24.9, and 25 or greater were 1.00 (reference), 1.06, 1.09, 1.39, and 1.33, respectively (p for trend = 0.02). For gain in BMI from age 20 years to age of the cohort at baseline, an inverse trend in risk was found (p for trend = 0.01), which did not persist after additional adjustment for BMI at age 20 (p for trend = 0.07). In subgroup analyses, no clear associations between anthropometry and advanced prostate cancer were found. Our findings suggest that body composition in young adulthood may already exert an effect on later risk of prostate cancer.
在荷兰队列研究中，作者调查了人体测量指标是否与前列腺癌风险相关。1986年基线时，58279名年龄在55至69岁之间的男性完成了一份关于饮食、人体测量指标及其他癌症风险因素的自填问卷。经过6.3年的随访，681例病例有基线时身高和体重的完整数据，523例病例有20岁时体重的数据。在年龄调整和多变量病例队列分析中（调整了年龄、前列腺癌家族史和社会经济地位），基线时的身高、体重指数（BMI；kg/m²）和去脂体重（kg）与前列腺癌风险无关。20岁时BMI小于19、19至20.9、21至22.9、23至24.9以及25或更高的男性患前列腺癌的率比分别为1.00（参照）、1.06、1.09、1.39和1.33（趋势p值 = 0.02）。对于从20岁到基线队列年龄期间BMI的增加，发现风险呈相反趋势（趋势p值 = 0.01），在对20岁时的BMI进行额外调整后该趋势不再存在（趋势p值 = 0.07）。在亚组分析中，未发现人体测量指标与晚期前列腺癌之间存在明确关联。我们的研究结果表明，青年期的身体组成可能已对后期前列腺癌风险产生影响。
