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心血管疾病的胎儿起源

Fetal origins of cardiovascular disease.

作者信息

Barker David J P

机构信息

a MRC Environmental Epidemiology Unit , University of Southampton , Southampton , UK.

出版信息

Ann Med. 1999;31(sup1):3-6. doi: 10.1080/07853890.1999.11904392.

DOI:10.1080/07853890.1999.11904392
PMID:28850284
Abstract

Low birthweight, thinness and short body length at birth are now known to be associated with increased rates of cardiovascular disease and non-insulin dependent diabetes in adult life. The fetal origins hypothesis proposes that these diseases originate through adaptations which the fetus makes when it is undernourished. These adaptations may be cardiovascular, metabolic or endocrine. They permanently change the structure and function of the body. Prevention of the diseases may depend on prevention of imbalances in fetal growth or imbalances between prenatal and postnatal growth, or imbalances in nutrient supply to the fetus.

摘要

现在已知出生时低体重、消瘦和身长较短与成年后患心血管疾病和非胰岛素依赖型糖尿病的几率增加有关。胎儿起源假说提出,这些疾病源于胎儿在营养不良时所做出的适应性变化。这些适应性变化可能是心血管、代谢或内分泌方面的。它们会永久性地改变身体的结构和功能。预防这些疾病可能取决于预防胎儿生长失衡、产前与产后生长失衡或胎儿营养供应失衡。

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