Barker D J, Gluckman P D, Godfrey K M, Harding J E, Owens J A, Robinson J S
MRC Environmental Epidemiology Unit, Southampton General Hospital, UK.
Lancet. 1993 Apr 10;341(8850):938-41. doi: 10.1016/0140-6736(93)91224-a.
Babies who are small at birth or during infancy have increased rates of cardiovascular disease and non-insulin-dependent diabetes as adults. Some of these babies have low birthweights, some are small in relation to the size of their placentas, some are thin at birth, and some are short at birth and fail to gain weight in infancy. This paper shows how fetal undernutrition at different stages of gestation can be linked to these patterns of early growth. The fetuses' adaptations to undernutrition are associated with changes in the concentrations of fetal and placental hormones. Persisting changes in the levels of hormone secretion, and in the sensitivity of tissues to them, may link fetal undernutrition with abnormal structure, function, and disease in adult life.
出生时或婴儿期体重小的婴儿成年后患心血管疾病和非胰岛素依赖型糖尿病的几率会增加。这些婴儿中有些出生体重低，有些相对于胎盘大小来说体型小，有些出生时很瘦，还有些出生时个子矮且在婴儿期体重未能增加。本文展示了孕期不同阶段的胎儿营养不良如何与这些早期生长模式相关联。胎儿对营养不良的适应与胎儿和胎盘激素浓度的变化有关。激素分泌水平以及组织对激素敏感性的持续变化，可能将胎儿营养不良与成年后的结构异常、功能异常及疾病联系起来。
