Emonts M, Meinders A E
Afd. Algemene Interne Geneeskunde, Leids Universitair Medisch Centrum, Leiden.
Ned Tijdschr Geneeskd. 2000 Mar 11;144(11):509-13.
The pathophysiology of heat stroke is not fully understood. Endotoxins and cytokines appear to play a major part in the central nervous system and in the peripheral tissues. Use of specific receptor blockers prior to heat exposure can diminish cerebral damage in animal experiments. The energy depletion model of Hubbard gives a possible explanation for the rhabdomyolysis observed in some heat stroke patients. Failure of the ATP dependent Na(+)-K+ pump is essential in this theory.
中暑的病理生理学尚未完全明了。内毒素和细胞因子似乎在中枢神经系统和外周组织中起主要作用。在热暴露前使用特定的受体阻滞剂可减少动物实验中的脑损伤。哈伯德的能量耗竭模型为一些中暑患者中观察到的横纹肌溶解提供了一种可能的解释。在该理论中，ATP依赖的钠钾泵功能衰竭至关重要。
