Ziprin P, Smith S, Salerno G, Rosin R D
Department of Surgery, St Mary's Hospital, London W2 1NY, U.K.
Br J Dermatol. 2000 Mar;142(3):525-8. doi: 10.1046/j.1365-2133.2000.03370.x.
Chronic lymphocytic leukaemia (CLL) has been associated with an increased incidence of second neoplasms, especially skin cancers such as basal and squamous cell carcinomas. No association with the rarer skin cancer, the Merkel cell tumour (MCT), has previously been reported. Two patients with MCT had a previous diagnosis of CLL. MCT is an aggressive skin cancer, as up to 45% of patients have lymph node involvement at presentation and 5-year disease-free survival is as low as 30%. It is most commonly found on sun-exposed areas of the body, and ultraviolet radiation together with drug-induced or CLL-induced immunosuppression may be the underlying mechanism in the observed relationship between CLL and other skin cancers.
慢性淋巴细胞白血病（CLL）与第二肿瘤的发病率增加有关，尤其是基底细胞癌和鳞状细胞癌等皮肤癌。此前尚未报道与较罕见的皮肤癌默克尔细胞肿瘤（MCT）有关联。两名患有MCT的患者曾被诊断为CLL。MCT是一种侵袭性皮肤癌，高达45%的患者在就诊时已有淋巴结受累，5年无病生存率低至30%。它最常见于身体暴露于阳光下的部位，紫外线辐射以及药物诱导或CLL诱导的免疫抑制可能是在CLL与其他皮肤癌之间观察到的关系的潜在机制。
