默克尔细胞多瘤病毒与默克尔细胞癌
Merkel cell polyomavirus and Merkel cell carcinoma.
作者信息
DeCaprio James A
机构信息
Department of Medical Oncology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA 02215, USA
Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, 450 Brookline Avenue, Boston, MA 02215, USA.
出版信息
Philos Trans R Soc Lond B Biol Sci. 2017 Oct 19;372(1732). doi: 10.1098/rstb.2016.0276.
Abstract
Merkel cell polyomavirus (MCPyV) causes the highly aggressive and relatively rare skin cancer known as Merkel cell carcinoma (MCC). MCPyV also causes a lifelong yet relatively innocuous infection and is one of 14 distinct human polyomaviruses species. Although polyomaviruses typically do not cause illness in healthy individuals, several can cause catastrophic diseases in immunocompromised hosts. MCPyV is the only polyomavirus clearly associated with human cancer. How MCPyV causes MCC and what oncogenic events must transpire to enable this virus to cause MCC is the focus of this essay.This article is part of the themed issue 'Human oncogenic viruses'.
摘要
默克尔细胞多瘤病毒（MCPyV）会引发一种极具侵袭性且相对罕见的皮肤癌，即默克尔细胞癌（MCC）。MCPyV还会引发一种终身性但相对无害的感染，它是14种不同的人类多瘤病毒之一。尽管多瘤病毒通常不会在健康个体中引发疾病，但有几种可在免疫功能低下的宿主中导致灾难性疾病。MCPyV是唯一一种与人类癌症明确相关的多瘤病毒。MCPyV如何引发MCC以及必须发生哪些致癌事件才能使这种病毒引发MCC是本文的重点。本文是主题为“人类致癌病毒”的特刊的一部分。
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